Manchester-based build-to-rent developer Placefirst has been granted permission to convert the former 32,000 sq ft job centre on Clarence Road into 53 apartments.
The three-storey building was previously occupied by the Department of Work & Pensions before closing in August 2018.
The £8m conversion, signed off by Manchester City Council, was designed by Altrincham-based Project 3 Architects and work to create a mix of one-, two- and three-bedroom apartments will begin next year.
A rooftop extension will also be created to house eight of the residential units.
David Mawson, chief executive of Placefirst, said: “Being a Manchester-based developer, the regeneration of this site in Longsight is very important to us.
“Being able to transform this former job centre into a thriving residential community will be hugely satisfying and will no doubt have a positive knock-on effect to the local area.”