The architecture practice has moved to the 26th floor of Bruntwood's building from 83 Fountain Street, Manchester.
3D Reid is an international architecture practice responsible for the design of One Angel Square, the new headquarters of the Cooperative Group, and a new Indigo Hotel next to Victoria Station.
It has taken 1,329 sq ft on a three-year lease at a rent of £17.50/sq ft, and has offices in London, Birmingham and Glasgow as well as Manchester.
Alex Russell, associate director of CBRE, said: "We managed to assemble a CBRE team to work closely with 3D Reid in order to find office space that suited its requirements.
"Bruntwood's proactive approach enabled us to secure this at City Tower."
Mike Hitchmough, divisional director and head of offices at 3D Reid, said: "Since establishing our Manchester office in 2006, we were keen that our new offices would provide a better working environment for our staff, clients and visitors.
"City Tower provides us with excellent office facilities that will support our future growth strategy for the practice."
The office agency team at CBRE North West advised on the move.